Title of article
Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers
Author/Authors
Hwa Sil Kim، نويسنده , , Yoonjee Kim، نويسنده , , Munikumar Reddy Doddareddy، نويسنده , , Seon Hee Seo، نويسنده , , Hyewhon Rhim، نويسنده , , Jinsung Tae، نويسنده , , Ae Nim Pae، نويسنده , , Hyunah Choo، نويسنده , , Yong Seo Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
476
To page
481
Abstract
A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC50 values of 0.93 and 0.96 μM, respectively.
Keywords
T-type calcium channel blockers , 1 , Pharmacophore model , 3-Dioxoisoindoline-5-carboxamides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797679
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