Title of article
Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors
Author/Authors
Junichi Sakamoto، نويسنده , , Tetsuo Koyama، نويسنده , , Daisei Miyamoto، نويسنده , , Sangchai Yingsakmongkon، نويسنده , , Kazuya I.P.J. Hidari، نويسنده , , Wipawee Jampangern، نويسنده , , Takashi Suzuki، نويسنده , , Yasuo Suzuki، نويسنده , , Yasuaki Esumi، نويسنده , , Ken Hatano، نويسنده , , Daiyo Terunuma، نويسنده , , Koji Matsuoka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
717
To page
721
Abstract
An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with α-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.
Keywords
Thioglycosides , Enzyme inhibitors , influenza virus , Sialidases , Glycoclusters , Sialic acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797726
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