Title of article
Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities
Author/Authors
Pingping Tang، نويسنده , , Fatemah Mamdani، نويسنده , , Xiaoyi Hu، نويسنده , , Jun O. Liu، نويسنده , , Biao Yu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1003
To page
1007
Abstract
Eight monosaccharide analogs of the potent antitumor OSW saponins (2–9) were synthesized. One analog, 2-O-acetyl-α-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC50 = 0.078 μM) comparable to that of the disaccharide derivative (1).
Keywords
OSW saponins , glycosides , Antiproliferative activities , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797781
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