Title of article
Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups—new classes of PPAR γ/δ and PPAR α/γ/δ agonists
Author/Authors
Louis-David Cantin، نويسنده , , Sidney Liang، نويسنده , , Herbert Ogutu، نويسنده , , Christiana I. Iwuagwu، نويسنده , , Ken Boakye، نويسنده , , William H. Bullock، نويسنده , , Michael Burns، نويسنده , , Roger Clark، نويسنده , , Thomas Claus، نويسنده , , Fernando E. delaCruz، نويسنده , , Michelle Daly، نويسنده , , Frederick J. Ehrgott، نويسنده , , Jeffrey S. Johnson، نويسنده , , Christine Keiper، نويسنده , , James N. Livingston، نويسنده , , Robert W. Schoenleber، نويسنده , , Jeffrey Shapiro، نويسنده , , Christopher Town، نويسنده , , Ling Yang، نويسنده , , Manami Tsutsumi، نويسنده , , et al.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
1056
To page
1061
Abstract
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands. Modification of the substituents on the linker and the heterocycle tail group allowed for the modulation of the selectivity at the different receptor subtypes. Compound 33 was evaluated in vivo, where it displayed the desired reduction of glucose levels and increase in HDL levels in various animal models.
Keywords
triglycerides , HDL , cholesterol , Diabetes , Indanyl acetic acid , PPAR agonist , cardiovascular , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797792
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