Title of article
Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides
Author/Authors
Yuanqing Tang، نويسنده , , Yuxiang Dong، نويسنده , , Sergio Wittlin، نويسنده , , Susan A. Charman، نويسنده , , Jacques Chollet، نويسنده , , Francis C.K. Chiu، نويسنده , , William N. Charman، نويسنده , , Hugues Matile، نويسنده , , Heinrich Urwyler، نويسنده , , Arnulf Dorn، نويسنده , , Saroj Bajpai، نويسنده , , Xiaofang Wang ، نويسنده , , Maniyan Padmanilayam، نويسنده , , Jean M. Karle، نويسنده , , Reto Brun، نويسنده , , Jonathan L. Vennerstrom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
1260
To page
1265
Abstract
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Keywords
1 , 4-Trioxolanes , Secondary ozonides , Antimalarial , peroxide , Artemisinin , 2
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797830
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