Title of article
Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure
Author/Authors
Simona M. Ceccarelli، نويسنده , , Georg Jaeschke، نويسنده , , Bernd Buettelmann، نويسنده , , J?rg Huwyler، نويسنده , , Sabine Kolczewski، نويسنده , , Jens-Uwe Peters، نويسنده , , Eric Prinssen، نويسنده , , Richard Porter، نويسنده , , Will Spooren، نويسنده , , Eric Vieira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1302
To page
1306
Abstract
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety.
Keywords
Fenobam , Anxiety , MPEP , Benzoxazolone , mGluR5
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797839
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