Title of article
Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold
Author/Authors
Luca Banfi، نويسنده , , Andrea Basso، نويسنده , , Gianluca Damonte، نويسنده , , Federico De Pellegrini، نويسنده , , Andrea Galatini، نويسنده , , Giuseppe Guanti، نويسنده , , Ilaria Monfardini، نويسنده , , Renata Riva، نويسنده , , Carlo Scapolla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1341
To page
1345
Abstract
The synthesis of new conformationally biased cyclic pentapeptides, incorporating the RGD sequence, and built around a tetrahydroazoninone scaffold, is reported. They exhibit interesting activity towards integrin αVβ3 and a remarkable selectivity in comparison with integrin αVβ5.
Keywords
Integrin ligands , peptidomimetics , angiogenesis , Azoninones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797846
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