• Title of article

    Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

  • Author/Authors

    Fides Benfatti، نويسنده , , Giuliana Cardillo، نويسنده , , Luca Gentilucci*، نويسنده , , Alessandra Tolomelli، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2007
  • Pages
    5
  • From page
    1946
  • To page
    1950
  • Abstract
    Unprecedented classes of four- and five-membered hydroxyl-spiro-β-lactams and hydroxyl-azido-β-lactams were prepared via regioselective ring opening of hydroxyl-epoxides. The potential of these particular β-lactams as biologically active compounds has been confirmed by the results obtained in ACAT inhibition assays.
  • Keywords
    Azides , Spiro derivatives , Cholesterol absorption inhibition , ?-Lactams , Acyl-CoA cholesterol O-acyltransferase
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2007
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797965

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797965