Title of article
Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1)
Author/Authors
Shenlin Huang، نويسنده , , Ronghua Li، نويسنده , , Peter J. Connolly، نويسنده , , Stuart Emanuel، نويسنده , , Angel Fuentes-Pesquera، نويسنده , , MARY ADAMS، نويسنده , , Robert H. Gruninger، نويسنده , , Jabed Seraj، نويسنده , , Steven A. Middleton، نويسنده , , Jeremy M. Davis، نويسنده , , David F.C. Moffat، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2179
To page
2183
Abstract
The series of 2-amino-4-aryl-5-chloropyrimidines was discovered to be potent for both VEGFR-2 and CDK1. Described here are the chemistry for analogue synthesis, SAR study, and its kinase selectivity prolifing. The full rat PK data and in vivo efficacy study are also included.
Keywords
CDK1 , VEGFR-2 , 2-Amino-4-aryl-5-chloropyrimidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798005
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