Title of article
Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3
Author/Authors
Qi-Huang Zheng، نويسنده , , Mingzhang Gao، نويسنده , , Bruce H. Mock، نويسنده , , Shuyan Wang، نويسنده , , Toshihiko Hara، نويسنده , , Rachid Nazih، نويسنده , , Michael A. Miller، نويسنده , , Tim J. Receveur، نويسنده , , John C. Lopshire، نويسنده , , William J. Groh، نويسنده , , Douglas P. Zipes، نويسنده , , Gary D. Hutchins، نويسنده , , Timothy R. DeGrado، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2220
To page
2224
Abstract
The high-affinity choline transporter (CHT1) system is an attractive target for the development of positron emission tomography (PET) biomarkers to probe brain, cardiac, and cancer diseases. An efficient and convenient synthesis of new radiolabeled CHT1 inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3 by solid-phase extraction (SPE) technique using a cation-exchange CM Sep-Pak cartridge has been well developed. The preliminary evaluation of both tracers through biodistribution studies in 9L-glioma rats has been performed, and the uptakes in the heart and tumor were observed, while very low brain uptake was seen.
Keywords
High-affinity choline transporter (CHT1) , Positron emission tomography (PET) , biodistribution
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798013
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