Title of article
Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B
Author/Authors
Ruslan V. Bikbulatov، نويسنده , , Feng Yan، نويسنده , , Bryan L. Roth، نويسنده , , Jordan K. Zjawiony، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2229
To page
2232
Abstract
To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural κ-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers.
Keywords
Semi-synthesis , ?-Opioid receptors agonists , Salvinorin A and B thioderivatives
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798015
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