Title of article
Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands
Author/Authors
John P. Caldwell، نويسنده , , Julius J. Matasi، نويسنده , , Hongtao Zhang، نويسنده , , Ahmad Fawzi، نويسنده , , Deen B. Tulshian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2281
To page
2284
Abstract
A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.
Keywords
Orphanin FQ , agonist , Nociceptin , NOP receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798026
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