Title of article
Optimization of Halopemide for Phospholipase D2 inhibition
Author/Authors
Lauren Monovich، نويسنده , , Benjamin Mugrage، نويسنده , , Elizabeth Quadros، نويسنده , , Karen Toscano، نويسنده , , Ruben Tommasi، نويسنده , , Stacey LaVoie، نويسنده , , H. Eugene Liu، نويسنده , , Zhengming Du، نويسنده , , Daniel LaSala، نويسنده , , William Boyar، نويسنده , , Paul Steed، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
2
From page
2310
To page
2311
Abstract
Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2.
Keywords
phospholipase D , inhibitor , Halopemide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798032
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