Title of article
Affinity-based ranking of ligands for DPP-4 from mixtures
Author/Authors
Gregory C. Adam، نويسنده , , Juncai Meng، نويسنده , , John Athanasopoulos، نويسنده , , Xiaoping Zhang، نويسنده , , Kevin T. Chapman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2404
To page
2407
Abstract
Affinity-based selection strategies have recently emerged as a complement to traditional high throughput screening for the rapid discovery of lead compounds for the large number of protein targets emerging from—omics technologies. Herein, we describe a method for the ranking of mixtures of ligands by affinity selection and apply it to rank order a set of inhibitors for the enzyme dipeptidyl peptidase IV.
Keywords
Affinity-based , Mass spectrometry , Rank ordering , Mixtures , dipeptidyl peptidase IV
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798050
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