Title of article
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model
Author/Authors
Fateh V. Singh، نويسنده , , Sumit Chaurasia، نويسنده , , Maya D. Joshi، نويسنده , , Arvind K. Srivastava، نويسنده , , Atul Goel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2425
To page
2429
Abstract
Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model.
Keywords
Antihyperglycemic , STZ-S model , Antidiabetic , Furanyl-2-pyranones , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798054
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