Title of article
Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury
Author/Authors
Rui Zhang، نويسنده , , Lin Lei، نويسنده , , Yun-Gen Xu، نويسنده , , Wei-Yi Hua، نويسنده , , Guo-Qing Gong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2430
To page
2433
Abstract
A novel series of benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines were designed and synthesized as Na+/H+exchanger inhibitors. Most of them were found to inhibit NHE1-mediated platelet swelling in a concentration-dependent manner, and to have significant cardioprotective effect against myocardial ischemic-reperfusion injury, among which compounds 10a and 34 were more potent than cariporide in both in vivo and in vitro tests.
Keywords
Na+/H+ exchanger , Na+/H+ exchanger inhibitors , Myocardial ischemic-reperfusion injury , synthesis , Benzoylguanidine derivatives
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798055
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