Title of article
Synthesis and biological evaluation of novel analogues of dictyostatin
Author/Authors
D. Ian Paterson، نويسنده , , Nicola M. Gardner، نويسنده , , Karine G. Poullennec، نويسنده , , Amy E. Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2443
To page
2447
Abstract
Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
Keywords
macrolide , anticancer , Tubulin , total synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798058
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