Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer’s disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD therapy. In this paper, the design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ -secretase inhibitors are described.