Title of article
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
Author/Authors
Jeff A. O’Meara، نويسنده , , Araz Jakalian، نويسنده , , Steven Laplante، نويسنده , , Pierre R. Bonneau، نويسنده , , René Coulombe، نويسنده , , Anne-Marie Faucher، نويسنده , , Ingrid Guse، نويسنده , , Serge Landry، نويسنده , , Jennifer Racine، نويسنده , , Bruno Simoneau، نويسنده , , Bounkham Thavonekham، نويسنده , , Christiane Yoakim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3362
To page
3366
Abstract
High-throughput screening hit 1 was identified as a potent, broad-spectrum, non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 replication. Analysis of the bound conformation of analogs of this inhibitor via molecular modeling and NMR contributed to the design of novel tertiary amide, carbamate, and thiocarbamate based NNRTIs.
Keywords
Tertiary amide , Tertiary carbamate , Thio-tetrazole , NNRTI , Scaffold hopping , Tetrazole thioacetanilide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798235
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