Title of article
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging
Author/Authors
Satish K. Chitneni، نويسنده , , Christophe M. Deroose، نويسنده , , Humphrey Fonge، نويسنده , , Rik Gijsbers، نويسنده , , Natalia Dyubankova، نويسنده , , Jan Balzarini، نويسنده , , Zeger Debyser، نويسنده , , Luc Mortelmans، نويسنده , , Alfons M. Verbruggen، نويسنده , , Guy M. Bormans، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3458
To page
3462
Abstract
An iodine-123 labeled bicyclic nucleoside analogue ([123I]-4) has been synthesized and evaluated as a potential single photon emission tomography (SPECT) reporter probe for the non-invasive imaging of expression of the varicella zoster virus thymidine kinase (VZV-tk) reporter gene. In vitro enzymatic assays revealed that the non-radioactive mono-iodo derivative 4 has good affinity for VZV-TK (IC50: 4.2 μM). Biodistribution of [123I]-4 was examined in normal mice. Evaluation of [123I]-4 in HEK-293T cells showed 1.74-fold higher accumulation in VZV-TK-expressing cells compared to control cells.
Keywords
BCNA , iodine-123 , molecular imaging , SPECT , Radiopharmaceutical
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798254
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