Title of article
Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 2: Structure–activity relationship studies on the benzopyran scaffold
Author/Authors
Timothy I. Richardson، نويسنده , , Bryan H. Norman، نويسنده , , Charles W. Lugar III، نويسنده , , Scott A. Jones، نويسنده , , Yong Wang، نويسنده , , Jim D. Durbin، نويسنده , , Venkatesh Krishnan، نويسنده , , Jeffrey A. Dodge، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3570
To page
3574
Abstract
Benzopyrans are selective estrogen receptor (ER) β agonists (SERBAs), which bind the ER subtypes α and β in opposite orientations. Here we describe structure–activity relationship studies that led to the discovery of bezopyran 5b. X-ray crystal structures of 5b and a non-selective analog 5c in ERα help explain the observed selectivity of the benzopyran platform.
Keywords
Estrogen receptor , ER? selective ligands , Benzopyrans
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798273
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