Title of article
Highly potent growth hormone secretagogues
Author/Authors
Zhijian Lu، نويسنده , , James R. Tata، نويسنده , , Kang Cheng، نويسنده , , Liente Wei، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget Butler، نويسنده , , Klaus D. Schleim، نويسنده , , Thomas M. Jacks، نويسنده , , Gerard Hickey، نويسنده , , Arthur A. Patchett، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
3657
To page
3659
Abstract
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H. L.; Hickey, G. J.; Smith, R. G.; Patchett, A. A. Bioorg. Med. Chem. Lett.1997, 7, 2319.]. Animal studies show that compound 8 can stimulate growth hormone release at the oral dose as low as 0.06 mpk. Chemistry and biological studies are discussed.
Keywords
Growth hormone secretagogues , Potent
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798289
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