Title of article
Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A
Author/Authors
Nicholas Aberle، نويسنده , , Jenny Catimel، نويسنده , , Edouard C. Nice، نويسنده , , Keith G. Watson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3741
To page
3744
Abstract
A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.
Keywords
Dehydrohydantoin , Naamidine A , structure–activity relationship , 2-Aminoimidazole , 2-Aminothiazole , Anti-tumor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798306
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