Title of article
C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase
Author/Authors
Sherrie L. Pietranico، نويسنده , , Louise H. Foley، نويسنده , , Nicholas Huby، نويسنده , , Weiya Yun، نويسنده , , Pete Dunten، نويسنده , , John Vermeulen، نويسنده , , Ping Wang، نويسنده , , Katherine Toth، نويسنده , , Gwendolyn Ramsey، نويسنده , , Mary-Lou Gubler، نويسنده , , Stanley J. Wertheimer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3835
To page
3839
Abstract
New modifications on the C-8 4-aminobenzyl unit of the previously reported 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most active compound reported here is the 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with an IC50 of 0.29 ± 0.08 μM. An X-ray analysis of a heteroaromatic sulfonamide is presented showing a new π–π interaction.
Keywords
Enzyme and cellular assays , cPEPCK inhibitors , x-ray , Xanthine class
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798322
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