Title of article
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds
Author/Authors
Hiroyuki Kai، نويسنده , , Yasuhide Morioka، نويسنده , , Minoru Tomida، نويسنده , , and Tadashi Takahashi، نويسنده , , Maki Hattori، نويسنده , , Kohji Hanasaki، نويسنده , , Katsumi Koike، نويسنده , , Hiroki Chiba، نويسنده , , Shunji Shinohara، نويسنده , , Toshiyuki Kanemasa، نويسنده , , Yuka Iwamoto، نويسنده , , Kohji Takahashi، نويسنده , , Yoshitaka Yamaguchi، نويسنده , , Takahiko Baba، نويسنده , , Takayoshi Yoshikawa، نويسنده , , Hideyuki Takenaka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3925
To page
3929
Abstract
Structure–activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798340
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