Title of article
Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine
Author/Authors
Alummoottil V. Joshua، نويسنده , , Sanjay K. Sharma، نويسنده , , Alicia Strelkov، نويسنده , , John R. Scott، نويسنده , , Mathew T. Martin-Iverson، نويسنده , , Douglas N. Abrams، نويسنده , , Peter H. Silverstone، نويسنده , , Alexander J.B. McEwan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4066
To page
4069
Abstract
8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D4-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.
Keywords
Clozapine , Iozapine , Schizophrenia , D4 receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798370
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