Title of article
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists
Author/Authors
Hiroki Fujieda، نويسنده , , Shinya Usui، نويسنده , , Takayoshi Suzuki، نويسنده , , Hidehiko Nakagawa، نويسنده , , Michitaka Ogura، نويسنده , , Makoto Makishima، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
4351
To page
4357
Abstract
To find novel PPARδ-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARδ agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARδ appropriately.
Keywords
PPAR? , Drug design , Nuclear receptor , agonist , metabolic syndrome
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798424
Link To Document