Title of article
Pyridinylimidazole inhibitors of Tie2 kinase
Author/Authors
Marcus Semones، نويسنده , , Yanhong Feng، نويسنده , , Neil Johnson، نويسنده , , Jerry L. Adams، نويسنده , , Jim Winkler، نويسنده , , Michael Hansbury، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4756
To page
4760
Abstract
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Keywords
Tie2 kinase , imidazole , xenograft
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798496
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