Title of article
Synthesis and structure–activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure
Author/Authors
Junichi Sakaki، نويسنده , , Kazuhide Konishi، نويسنده , , Masashi Kishida، نويسنده , , Hiroki Gunji، نويسنده , , Takanori Kanazawa، نويسنده , , Hidefumi Uchiyama، نويسنده , , Hiroaki Fukaya، نويسنده , , Hironobu Mitani، نويسنده , , Masaaki Kimura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4808
To page
4811
Abstract
Synthesis and structure–activity relationship of RXR antagonists employing a diazepinylbenzoic acid scaffold are described. Of those antagonists, sulfonamide derivatives (6v and 6w) reveal a high antagonistic activity and good pharmacokinetic properties.
Keywords
RXR , Diazepinylbenzoic acid , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798506
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