Title of article
Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF1 receptor antagonists
Author/Authors
MARIA GABRIELLA GENTILE، نويسنده , , Romano Di Fabio، نويسنده , , Francesca Pavone، نويسنده , , Fabio Maria Sabbatini، نويسنده , , Yves St-Denis، نويسنده , , Maria Grazia Zampori، نويسنده , , Giovanni Vitulli، نويسنده , , Angela Worby، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
5218
To page
5221
Abstract
Corticotropin-releasing factor (CRF), a 41 amino acid peptide neurohormone synthesised by specific hypothalamic nuclei in the brain, is implicated in stress-related function. Antagonism of CRF1 receptors is an attractive therapeutic approach for the treatment of depression and anxiety. Unsaturated tetrahydrotriazaacenaphthylenes of general structure 3 have been identified as potent and selective CRF1 receptor antagonists with a suitable oral pharmacokinetic profile.
Keywords
CRF1 antagonists , Anxiety , depression , Corticotropin-releasing factor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798586
Link To Document