Title of article
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
Author/Authors
Pi Cheng، نويسنده , , Yun-bao Ma، نويسنده , , Shu-ying Yao، نويسنده , , Quan Zhang، نويسنده , , En-jun Wang، نويسنده , , Meng-hong Yan، نويسنده , , Xuemei Zhang، نويسنده , , Feng-xue Zhang، نويسنده , , Ji-Jun Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5316
To page
5320
Abstract
Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaceae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line.
Keywords
Anti-HBV activity , Hypserpa nitida , Menispermaceae , Hypserpanine A , Hypserpanine B , Structure elucidation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798604
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