Title of article
Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies
Author/Authors
Claudia Mugnaini، نويسنده , , Suvi Rajamaki، نويسنده , , Cristina Tintori، نويسنده , , Federico Corelli، نويسنده , , Silvio Massa، نويسنده , , Myriam Witvrouw، نويسنده , , Zeger Debyser، نويسنده , , Veljko Veljkovic، نويسنده , , Maurizio Botta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
5370
To page
5373
Abstract
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC50 = 12 μM.
Keywords
Integrase inhibitors , HIV-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798616
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