Title of article
Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents
Author/Authors
Dae-Seop Shin، نويسنده , , Jiin Kim، نويسنده , , Dong Cho Han، نويسنده , , Kwang-Hee Son، نويسنده , , Chang Woo Lee، نويسنده , , Hwan-Mook Kim، نويسنده , , Su-Hyung Hong، نويسنده , , Byoung-Mog Kwon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5423
To page
5427
Abstract
A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
Keywords
Cinnamaldehyde , Apoptosis , Cell cycle
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798627
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