Title of article
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus
Author/Authors
Subharekha Raghavan، نويسنده , , Zhijian Lu، نويسنده , , Teresa Beeson، نويسنده , , Kevin T. Chapman، نويسنده , , William A. Schleif، نويسنده , , David B. Olsen، نويسنده , , Mark Stahlhut، نويسنده , , Carrie A. Rutkowski، نويسنده , , Lori Gabryelski، نويسنده , , Emilio Emini، نويسنده , , James R. Tata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5432
To page
5436
Abstract
A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
Keywords
HIV , protease inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798629
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