Title of article
Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activities
Author/Authors
Chunyang Jin، نويسنده , , G. Manikumar، نويسنده , , John A. Kepler، نويسنده , , C. Edgar Cook، نويسنده , , George F. Allan، نويسنده , , Margaret Kiddoe، نويسنده , , Sheela Bhattacharjee، نويسنده , , Olivia Linton، نويسنده , , Scott G. Lundeen، نويسنده , , Zhihua Sui، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
5754
To page
5757
Abstract
A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486).
Keywords
Steroidal spiro-oxazole , progesterone receptor , Selective progesterone receptor modulators , Glucocorticoid receptor , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798691
Link To Document