Title of article
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA–topoisomerase I complex
Author/Authors
Hue Thi My Van، نويسنده , , Quynh Manh Le، نويسنده , , Kwang Youl Lee، نويسنده , , Eung Seok Lee، نويسنده , , Youngjoo Kwon، نويسنده , , Tae Sung Kim، نويسنده , , Thanh Nguyen Le، نويسنده , , Suh-Hee Lee، نويسنده , , Won-Jea Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5763
To page
5767
Abstract
11-Hydroxyindeno[1,2-c]isoquinolines 12a–c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.
Keywords
Indenoisoquinoline , Docking study , Antitumor agents , synthesis , cytotoxicity , Topoisomerase 1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798693
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