Title of article
Synthesis and structure–activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors
Author/Authors
Madhavi Pannala، نويسنده , , Sunil Kher، نويسنده , , Norma Wilson، نويسنده , , John Gaudette، نويسنده , , Ila Sircar، نويسنده , , Shao-Hui Zhang، نويسنده , , Alexei Bakhirev، نويسنده , , Guang Yang، نويسنده , , Phoebe Yuen، نويسنده , , Frank Gorcsan، نويسنده , , Naoki Sakurai، نويسنده , , Miguel Barbosa، نويسنده , , Jie-Fei Cheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5978
To page
5982
Abstract
Synthesis and structure–activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as well as in the functional cellular assay. They are moderately selective against other types of tyrosine kinases.
Keywords
Quinoline-3-carbonitrile , EGFR inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798733
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