Title of article
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
Author/Authors
Hyun-Soon Chong، نويسنده , , Santosh Mhaske، نويسنده , , Mai-Lin Liang، نويسنده , , Sankar Bhuniya، نويسنده , , Hyun A. Song، نويسنده , , Martin W. Brechbiel، نويسنده , , Xiankai Sun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6107
To page
6110
Abstract
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA–Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with 64Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA–Bn form stable complexes with 64Cu.
Keywords
Cu-64 , Serum stabilityArticle Outline , targeted radiotherapy , PET imaging , Synthetic chelates , Macrocyclic ligands
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798754
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