Title of article
Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1
Author/Authors
Michele C. Jetter، نويسنده , , Mark A. Youngman، نويسنده , , James J. McNally، نويسنده , , Mark E. McDonnell، نويسنده , , Sui-Po Zhang، نويسنده , , Adrienne E. Dubin، نويسنده , , Nadia Nasser، نويسنده , , Ellen E. Codd، نويسنده , , Christopher M. Flores، نويسنده , , Scott L. Dax، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6160
To page
6163
Abstract
We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure–activity relationships (SAR) of the series are described.
Keywords
trpv1 , Antagonists , Tetralin ureas
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798766
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