Title of article
Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists
Author/Authors
Jeffrey W. Corbett، نويسنده , , Mark R. Rauckhorst، نويسنده , , Fang Qian، نويسنده , , Robert L. Hoffman، نويسنده , , Christopher S. Knauer، نويسنده , , Lawrence W. Fitzgerald، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
6250
To page
6256
Abstract
Low nanomolar corticotropin releasing factor type-1 (CRF1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a Ki = 11 ± 1 nM. The oxygen-linked pyrazinyl derivatives were prepared through a copper-catalyzed coupling of a pyridinone to a bromo- or iodopyrazine.
Keywords
CRH1 , CRF1 , Corticotropin releasing factor type-1 antagonist , pyrazine , Corticotropin releasing hormone type-1 , Copper-mediated coupling
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798785
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