Title of article
2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2
Author/Authors
Danielle K. Neff، نويسنده , , Alice Lee-Dutra، نويسنده , , Jonathan M. Blevitt، نويسنده , , Frank U. Axe، نويسنده , , Michael D. Hack، نويسنده , , Johnathan C. Buma، نويسنده , , Raymond Rynberg، نويسنده , , Anders Brunmark، نويسنده , , Lars Karlsson، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6467
To page
6471
Abstract
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.
Keywords
Chk2 , Cds1 , Aminoalcohol , Solubility , Mitsunobu
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798826
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