Title of article
Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy
Author/Authors
Byung Seok Moon، نويسنده , , Moon-Taek Park، نويسنده , , Jeong Hoon Park، نويسنده , , Sang-Wook Kim، نويسنده , , Kyo Chul Lee، نويسنده , , Gwang Il Kim، نويسنده , , Seung Dae Yang، نويسنده , , Dae Yoon Chi، نويسنده , , Gi-Jeong Cheon، نويسنده , , Su-Jae Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6643
To page
6646
Abstract
Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
Keywords
Radiosensitizer , sphingolipids , Phytoceramide , Phytosphingosine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798861
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