Title of article
Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2
Author/Authors
Kumiko Takeuchi، نويسنده , , William G. Holloway، نويسنده , , Charles H. Mitch، نويسنده , , Steven J. Quimby، نويسنده , , Jamie H. McKinzie، نويسنده , , Todd M. Suter، نويسنده , , Michael A. Statnick، نويسنده , , Peggy L. Surface، نويسنده , , Paul J. Emmerson، نويسنده , , Elizabeth M. Thomas، نويسنده , , Miles G. Siegel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
6841
To page
6846
Abstract
A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.
Keywords
Opioid receptor antagonists (OpRAs) , Carboxamido-biaryl ethers , obesity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798897
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