Title of article
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
Author/Authors
Jens-Uwe Peters، نويسنده , , Thomas Lübbers، نويسنده , , Alexander Alanine، نويسنده , , Sabine Kolczewski، نويسنده , , Francesca Blasco، نويسنده , , Lucinda Steward، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
256
To page
261
Abstract
The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.
Keywords
5-HT , GPCR , SAR , guanidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798958
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