Title of article
Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents
Author/Authors
Denis Girard، نويسنده , , Glenn Weagle، نويسنده , , Atul Gupta، نويسنده , , Gervais Bérubé، نويسنده , , Camille Chapados، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
360
To page
365
Abstract
Tetrapyrrole ethanolamide derivatives, 1 and 2, were prepared from hematoporphyrin IX (HPIX, 3) and methyl pheophorbide a (mPheo, 6). These were evaluated for their dual action as chemotherapeutics and photosensitizers in treatment of cancer. The novel compounds showed significant in vitro anticancer activity as measured in different cell lines using the MTT assay and photodynamic activity measured by erythrocytes’ photohemolysis.
Keywords
Pheophorbide ethanolamide , Hematoporphyrin , photodynamic therapy , Hematoporphyrin propylether ethanolamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798978
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