Title of article
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)
Author/Authors
Yue Mei Zhang، نويسنده , , Xiaodong Fan، نويسنده , , Shyh-Ming Yang، نويسنده , , Robert H. Scannevin، نويسنده , , Sharon L. Burke، نويسنده , , Kenneth J. Rhodes، نويسنده , , Paul F. Jackson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
405
To page
408
Abstract
Several classes of arylsulfone-based MMP-2/-9 inhibitors utilizing 6- to 8-membered heterocyclic rings as zinc-binding groups (ZBGs) have been synthesized and their enzyme inhibitory activities were evaluated. Although a number of 6- and 7-membered heterocycles were effective, the most potent arylsulfone inhibitors are based on the rigid 1- or 3-hydroxypyridone ZBG.
Keywords
MMP-2 , MMP-9 , Zinc-binding group , Arylsulfone , Matrix metalloproteinase inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798987
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