Title of article
Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
Author/Authors
Samir A. Carvalho، نويسنده , , Edson F. da Silva، نويسنده , , Marcus V.N. de Souza، نويسنده , , Maria C.S. Lourenço، نويسنده , , Felipe R. Vicente، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
538
To page
541
Abstract
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a–d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.
Keywords
Isoniazid , tuberculosis , antimycobacterial activity , Trans-cinnamic acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799011
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