Title of article
1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity
Author/Authors
Gavin A. Whitlock، نويسنده , , Julian Blagg، نويسنده , , Paul V. Fish، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
596
To page
599
Abstract
A novel series of 1-(2-phenoxyphenyl)methanamines is disclosed, which possess selective dual 5-HT and NA reuptake pharmacology. Analogues with good human in vitro metabolic stability, hERG selectivity and passive membrane permeability were identified.
Keywords
Serotonin , noradrenaline , Metabolic stability , Monoamine reuptake inhibitor , hERG affinity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799021
Link To Document