Title of article
Design and optimization of imidazole derivatives as potent CXCR3 antagonists
Author/Authors
Xiaohui Du، نويسنده , , Xiaoqi Chen، نويسنده , , Jeffrey T. Mihalic، نويسنده , , Jeffrey Deignan، نويسنده , , Jason Duquette، نويسنده , , An-Rong Li، نويسنده , , Bryan Lemon، نويسنده , , Hong-Ji Ma and Rui Nie، نويسنده , , Shichang Miao، نويسنده , , Karen Ebsworth، نويسنده , , Timothy J.Sullivan، نويسنده , , George Tonn، نويسنده , , Tassie L. Collins، نويسنده , , Julio C. Medina، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
608
To page
613
Abstract
A series of imidazole derivatives have been designed and optimized for CXCR3 antagonism, pharmacokinetic properties, and reduced formation of glutathione conjugates. Our efforts led to the discovery of potent CXCR3 antagonists with good pharmacokinetic properties. These compounds are useful tools for in vivo studies of CXCR3 function.
Keywords
CXCR3 , ITAC , CXCL9 , CXCL10 , MIG , CXCL11 , imidazole , chemokine , IP10
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799024
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