Title of article
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite
Author/Authors
David N. Deaton، نويسنده , , Enoch N. Gao، نويسنده , , Kevin P. Graham، نويسنده , , Jeffrey W. Gross، نويسنده , , Aaron B. Miller، نويسنده , , John M. Strelow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
732
To page
737
Abstract
Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P1 benzyl moiety led to improvements in ACE2 potency as well as to increased selectivity versus ACE and NEP.
Keywords
Angiotensin-converting enzyme 2 , metalloproteases , protease inhibitors , thiols
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799049
Link To Document